The asymmetric ester enolate Claisen rearrangement as a suitable method for the synthesis of sterically highly demanding amino acids
1996; Elsevier BV; Volume: 37; Issue: 44 Linguagem: Inglês
10.1016/0040-4039(96)01764-9
ISSN1873-3581
Autores Tópico(s)Synthetic Organic Chemistry Methods
ResumoEster enolate Claisen rearrangement of highly substituted glycine allylic esters under the influence of chiral ligands gives rise to sterically demanding amino acids. The reaction yields amino acids with a β-quaternary carbon center in a highly diastereo -and enantioselective manner, and could be applied to a wide scope of different classes of amino acids.
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