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Inhibitory effects of 6-hydroxydopamine on the clonic convulsions induced by electroshock and decapitation

1975; Elsevier BV; Volume: 14; Issue: 8 Linguagem: Inglês

10.1016/0028-3908(75)90124-0

1873-7064

Takeo Fukuda, Yasunori Araki, Noriko Suenaga,

Botulinum Toxin and Related Neurological Disorders

Effects of intraventricular injection of 6-hydroxydopamine (6-OHDA) on maximal electroshock seizures and decapitation convulsions were investigated in mice. The incidence of the clonic phase of maximal electroshock seizure was suppressed by 6-OHDA. The time course of the suppression was in good agreement with the decreased level of whole brain norepinephrine. The incidence of clonic convulsions following decapitation was also suppressed by 6-OHDA. On the contrary, the tonic phase of maximal electroshock seizure was potentiated by the treatment. The incidence of the clonic phase of maximal electroshock seizure and of decapitation convulsions were well correlated in 6-OHDA treated mice which had been exposed to maximal electroshock seizure and then decapitated. It is suggested that the central catecholaminergic mechanism concerned with the clonic phase in maximal electroshock seizure is analogous to that concerned with decapitation convulsions and different from that underlying the tonic phase of maximal electroshock seizure.