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Effect of Propranolol on Elevated Arterial Blood Pressure

1968; Lippincott Williams & Wilkins; Volume: 37; Issue: 4 Linguagem: Inglês

10.1161/01.cir.37.4.534

1524-4539

D. C. Richardson, Jack Freund, Arthur S. Gear, H. Page Mauck, Lester W. Preston,

Hormonal Regulation and Hypertension

Nineteen patients with moderately severe arterial hypertension received propranolol (120 mg daily), or chlorthalidone (100 mg daily), both medications together, and placebos in a double-blind crossover trial. Each treatment was given for 5 weeks; blood pressure was measured at weekly intervals. Propranolol alone reduced arterial pressure by 9/8 mm Hg, a statistically insignificant change. Use of chlorthalidone alone was accompanied by an average reduction in arterial blood pressure of 23/9 mm Hg. Both drugs together lowered blood pressure by 33/15 mm Hg. Heart rate was lower in regimens including propranolol; body weight and serum potassium and chloride concentration were lower and blood urea nitrogen and serum creatinine were higher in regimens containing chlorthalidone. Propranolol, in the dose given, is a less effective hypotensive drug than is chlorthalidone.