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Effect of Urethral Dilation on Vesical Motor Activity: Identification of the Urethrovesical Reflex and its Role in Voiding

2003; Lippincott Williams & Wilkins; Volume: 169; Issue: 3 Linguagem: Inglês

10.1097/01.ju.0000046384.71563.51

1527-3792

Ahmed Shafik, Olfat El‐Sibai, Ismail Ahmed,

Neuroscience of respiration and sleep

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2003Effect of Urethral Dilation on Vesical Motor Activity: Identification of the Urethrovesical Reflex and its Role in Voiding AHMED SHAFIK, OLFAT EL-SIBAI, and ISMAIL AHMED AHMED SHAFIKAHMED SHAFIK More articles by this author , OLFAT EL-SIBAIOLFAT EL-SIBAI More articles by this author , and ISMAIL AHMEDISMAIL AHMED More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000046384.71563.51AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the hypothesis that mild urethral distention, which presumably occurs during the passage of urine through the urethra, stimulates stretch receptors in the urethral wall, leading reflexively to vesical contraction. Materials and Methods: We evaluated 9 male and 10 female healthy volunteers with a mean age ± SD of 39.6 ± 8.3 years. The posterior urethra was distended by a balloon filled with saline in 1 ml. increments up to 6 ml., while recording vesical pressure. The test was repeated after individual anesthetization of the urethra and bladder. Results: Vesical pressure increased significantly at 1 and 2 ml. urethral distention (p <0.01). Increases in urethral distention effected further vesical pressure elevation (p 0.05). No significant vesical pressure response of the individually anesthetized urethra or bladder occurred during urethral distention. Conclusions: Urethral distention is thought to cause vesical contraction through the stimulation of urethral stretch receptors. Vesical contraction at urethral distention postulates a reflex relationship that was abolished by individual anesthetization of the urethra and bladder. This relationship, which we call the urethrovesical reflex, appears to have a role in maintaining vesical contraction during voiding. 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Link, Google Scholar From the Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo and Department of Surgery, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byEggermont M, Wyndaele J, Gillespie J and De Wachter S (2018) Response Properties of Urethral Distension Evoked Unifiber Afferent Potentials in the Lower Urinary TractJournal of Urology, VOL. 194, NO. 5, (1473-1480), Online publication date: 1-Nov-2015.Yoo P, Horvath E, Amundsen C, Webster G and Grill W (2018) Multiple Pudendal Sensory Pathways Reflexly Modulate Bladder and Urethral Activity in Patients With Spinal Cord InjuryJournal of Urology, VOL. 185, NO. 2, (737-743), Online publication date: 1-Feb-2011.Woock J, Yoo P and Grill W (2018) Intraurethral Stimulation Evokes Bladder Responses via 2 Distinct Reflex PathwaysJournal of Urology, VOL. 182, NO. 1, (366-373), Online publication date: 1-Jul-2009.Shafik A (2018) RE: A CATHETER BASED METHOD TO ACTIVATE URETHRAL SENSORY NERVE FIBERSJournal of Urology, VOL. 172, NO. 1, (388-388), Online publication date: 1-Jul-2004. Volume 169Issue 3March 2003Page: 1017-1019 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsurethrabladderballoon dilatationreflexurinationMetricsAuthor Information AHMED SHAFIK More articles by this author OLFAT EL-SIBAI More articles by this author ISMAIL AHMED More articles by this author Expand All Advertisement PDF downloadLoading ...