Compartmental analysis of calcium kinetics in man: Application of a four-compartmental model
1974; Elsevier BV; Volume: 23; Issue: 5 Linguagem: Inglês
10.1016/0026-0495(74)90088-2
ISSN1532-8600
AutoresJEAN PIERRE MASSIN, Gabriel Vallée, J C Savoie,
Tópico(s)Bone health and treatments
Resumo45Ca kinetic data was obtained in seven normal subjects and in 22 pathologic conditions. The specific radioactivities of the serum were measured over a period of 10–14 days. They were carried out by liquid scintillation counting after purification of the serum calcium by cationic exchange resin chromatography. The data was automatically analyzed by a program that determines the fitness of different possible multiexponential solutions. This program showed that the best solution is the sum of four exponential functions. The exchangeable calcium pool and the amounts transferred have been calculated according to a pure mammillary model. The observed mean normal values, recal-culated for the standard body surface (1.73 sq m), were: (1) total exchangeable pool, 5.52g; (2) accessible (central) compartment I = 1.07 g; (3) the three peripheral compartments II = 0.70 g; III = 1.60 g; IV = 2.14 g; (4) the transfer rates, I–II = 29 g/day; I–III = 6.4 g/day; I–IV = 1.1 g/day; (5) total turnover, 0.75 g/day; and (6) accretion, 420 mg/day. Significant deviations from the normal of one or several parameters of this model were found in hyperparathyroidism (eight cases), hypoparathyroidism (four cases), osteoporosis (six cases), osteomalacia (two cases), and bone metastasis (two cases). Dependency of the various parameters of the model on each other was tested by correlation analysis. The validity of the compartmental analysis is discussed.
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