HLA CLASS II POLYMORPHISM AND IDDM SUSCEPTIBILITY IN THE GREEK POPULATION
1993; Wiley; Volume: 20; Issue: 3 Linguagem: Inglês
10.1111/j.1744-313x.1993.tb00110.x
ISSN1744-313X
AutoresI Khalil, M. Spyropoulou, C. Mallet, M.N. Loste, Corinne Douay, J. Laperriere, C.A. Bartzokas, V. Lepage, Dominique Charron, Catherine Stavropoulos,
Tópico(s)Immune Cell Function and Interaction
ResumoSUMMARY The frequencies of HLA‐DQA1, DQB1 and DRB1 alleles were compared between 50 Insulin‐Dependent Diabetes Melitus (IDDM) patients and 49 healthy controls in the Greek population. Statistically significant difference in the frequencies of HLA‐DQA1*0501‐DQB1*0201 (P = 10 ‐4 ), DQA1*0301‐DQB1*0201 ( P = 0.01) and DQA P0301‐DQB 1*0302 ( P = 0.001) were observed. The DRB1*0405‐DQA1*0301‐DQB 1*0201 was the only DR, DQ combination significantly associated with the disease. The unexpected increase of DRB1*0405 observed in the Greek IDDM may suggest as reported in Chinese and Japanese IDDM a contribution of DRβ and DQα in susceptibility. Moreover, in contrast to the Asians, in the Greek, the DRβ, DQα are found with the usual DQβ 57‐ve.
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