Pharmacokinetics and ventilatory effects of oxycodone before and after liver transplantation*
1997; Wiley; Volume: 61; Issue: 6 Linguagem: Inglês
10.1016/s0009-9236(97)90100-4
ISSN1532-6535
AutoresMinna Tallgren, Klaus T. Olkkola, Timo Seppαlä, K. Höckerstedt, L. Lindgren,
Tópico(s)Drug-Induced Hepatotoxicity and Protection
ResumoThe pharmacokinetics and ventilatory effects of oxycodone were studied in six volunteer patients with end-stage liver cirrhosis before and after orthotopic liver transplantation. Plasma samples and urine were collected for 24 hours after intravenous administration of 0.05 mg/kg oxycodone hydrochloride. Concentrations of oxycodone and its metabolites, noroxycodone and oxymorphone, were measured in plasma and urine. The median elimination half-life of oxycodone was 13.9 hours (range, 4.6 to 24.4 hours) in patients with cirrhosis before transplantation and 3.4 hours (range, 2.6 to 5.1 hours) after transplantation (p < 0.05). Correspondingly, oxycodone clearance increased from 0.26 L/min (range, 0.15 to 0.73 L/min) before transplantation to 1.13 L/min (range, 0.71 to 3.98 L/min) after transplantation (p < 0.05). Oxycodone depress edventilation more strongly before transplantation than after transplantation (p < 0.05). Care should be exercised when oxycodone is used in patients with end-stage liver disease. Clinical Pharmacology & Therapeutics (1997) 61, 655–661; doi:
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