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Expanding role of AMPK in endocrinology

2006; Elsevier BV; Volume: 17; Issue: 5 Linguagem: Inglês

10.1016/j.tem.2006.05.006

1879-3061

Blerina Kola, Marco Boscaro, Guy A. Rutter, Ashley Grossman, Márta Korbonits,

Diet, Metabolism, and Disease

Adenosine 5′ monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome.