Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling
2011; American Association for the Advancement of Science; Volume: 334; Issue: 6056 Linguagem: Inglês
10.1126/science.1212782
ISSN1095-9203
AutoresSeung Chul Shin, Sunghee Kim, Hye Jin You, Boram Kim, Aeri C. Kim, Kyung‐Ah Lee, Joo‐Heon Yoon, Ji-Hwan Ryu, Won‐Jae Lee,
Tópico(s)Insect symbiosis and bacterial influences
ResumoThe symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH.
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