Portal de Periódicos da CAPES

Tissue-specific mosaicism for trisomy 21 and congenital heart disease

1992; Elsevier BV; Volume: 121; Issue: 1 Linguagem: Inglês

10.1016/s0022-3476(05)82547-8

1097-6833

Yuji Yokoyama, Kouji Narahara, Masahiro Kamada, Kazushiro Tsuji, Yoshiki Seino,

Congenital heart defects research

Cytogenetic studies in a girl with ventricular septal defect and mosaicism for trisomy 21 showed that trisomy was present in most cells from the myocardium and lung but in only a minority from the skin and lymphocytes. These findings emphasize the importance of tissue-specific mosaicism as a cause of certain cardiovascular diseases. Cytogenetic studies in a girl with ventricular septal defect and mosaicism for trisomy 21 showed that trisomy was present in most cells from the myocardium and lung but in only a minority from the skin and lymphocytes. These findings emphasize the importance of tissue-specific mosaicism as a cause of certain cardiovascular diseases.