Produção Nacional
Revisado por pares
A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma
2007; Wiley; Volume: 6; Issue: 1 Linguagem: Inglês
10.1111/j.1473-2165.2007.00288.x
ISSN1473-2165
AutoresTânia Ferreira Cestari, Karime Marques Hassun, Alexandre Sittart, Maria de Lourdes VIEGAS,
Tópico(s)Hair Growth and Disorders
ResumoSummary The aim of this study was to compare the efficacy and safety of a triple combination (TC) cream and monotherapy with hydroquinone (HQ) cream in the treatment of moderate to severe facial melasma. A total of 120 patients applied TC cream once daily or HQ cream twice daily for 8 weeks. Evaluations included static global severity assessment of melasma, improvement of melasma over time, local tolerability, and adverse events. TC cream was significantly more effective than HQ cream from week 4 onwards: lesions were approximately equivalent to the surrounding skin in 35% of all TC‐treated patients, compared to 5% of those who used HQ cream ( P = 0.0001). Improvement of more than 75% was achieved by 73% of TC cream patients and 49% of HQ cream patients ( P = 0.007). The incidence of adverse events (erythema, burning sensation, and desquamation) was similar in both groups. No patient dropped out of the study because of drug‐related adverse events. TC cream was more effective than the HQ cream for the treatment of moderate to severe facial melasma. Both products had similar safety profiles.
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