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ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

2006; Royal Society of Chemistry; Issue: 2 Linguagem: Inglês

10.1039/b611122j

1364-548X

Angela Casini, Guido Mastrobuoni, Claudia Temperini, Chiara Gabbiani, Simona Francese, Gloriano Moneti, Claudiu T. Supuran, Andrea Scozzafava, Luigi Messori,

Nanoparticle-Based Drug Delivery

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug–protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.