Portal de Periódicos da CAPES

Drug Interactions with Quinolones

1988; Oxford University Press; Volume: 10; Issue: Supplement_1 Linguagem: Inglês

10.1093/clinids/10.supplement_1.s132

1537-6591

H. Lode,

Antibiotic Resistance in Bacteria

The mechanisms involved in drug interactions may be either pharmacokineticor pharmacodynamic. Pharmaco kinetic interactions are the leading events and are caused by alterations in absorption, distribution, metabolism, and elimination of one drug by another. The reported interactions of new quinolones are due to a decrease in antimicrobial activity at low pH, a Mg++-dependent reduction in efficacy, and a probenecid-induced decrease in tubular secretion of ciprofloxacin. The reduction of theophylline clearance by those quinolones that are metabolized primarilyin the liver(enoxacin and ciprofloxacin) isof clinical relevance; also, the interactions of quinolones with Mg++-containing antacids, which result in tremendous loss of bioavailability, are of therapeutic importance.