Effect of Alinidine on Experimental Cardiac Arrhythmias
1982; Lippincott Williams & Wilkins; Volume: 4; Issue: 2 Linguagem: Inglês
10.1097/00005344-198203000-00009
ISSN1533-4023
AutoresD. W. G. Harron, John Allen, Robert F. Wilson, R.G. Shanks,
Tópico(s)Ion channel regulation and function
ResumoSummary Alinidine (2.9 ± 0.7 mg/kg) prevented an adrenaline-induced ventricular arrhythmia in dogs respired with halothane. In ouabain-induced ventricular tachycardia, a cumulative dose of alinidine (15.5 mg/kg) reduced the number of ventricular beats by 91.6 ± 1.9%. The drug was much less effective in abolishing the ventricular tachycardia 24 h after ligation of a coronary artery, with only a 36 ± 15% reduction in ventricular ectopic beats after 15.5 mg/kg. The administration of alinidine (0.5–1.0 mg/kg) to anaesthetized dogs with no cardiac arrhythmia reduced sinus node rate with little effect on the response of the node to vagal stimulation.
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