A Study of the Interaction between Progesterone and Membrane Lipids *
1983; Oxford University Press; Volume: 113; Issue: 1 Linguagem: Inglês
10.1210/endo-113-1-190
ISSN1945-7170
AutoresJohn C. Carlson, Margaret Y. Gruber, J. E. Thompson,
Tópico(s)Surfactants and Colloidal Systems
ResumoThe ability of progesterone to associate with phospholipid was examined in a model membrane system. Molecular interaction was assessed by measuring the enthalpy of the phase transition of dipalmitoylphosphatidylcholine lipo-somes by differential scanning calorimetry. The response was compared to cholesterol, a constituent of cellular membranes. Unlike cholesterol, progesterone caused minimal disruption of the phospholipid bilayer phase properties at concentrations ranging from 5–33 mol %. However, it interacted with the phospholipid to a greater degree when cholesterol was included in the liposomes. These results indicate that progesterone can intercalate into phospholipid bilayers containing cholesterol, and raise the prospect that there may be some diffusion of the hormone across the plasma membrane. (Endocrinology113: 190, 1983)
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