Pharmacokinetics of ifosfamide and its enantiomers following a single 1 h intravenous infusion of the racemate in patients with small cell lung carcinoma.
1995; Wiley; Volume: 39; Issue: 4 Linguagem: Inglês
10.1111/j.1365-2125.1995.tb04477.x
ISSN1365-2125
AutoresSarah Corlett, D. Parker, Henry Chrystyn,
Tópico(s)Safe Handling of Antineoplastic Drugs
ResumoIfosfamide is a chiral pro‐drug which is administered clinically in its racemic form. Serum concentrations of rac‐ifosfamide and its enantiomers were measured in 12 patients with lung carcinoma following a mean (+/‐ s.d.) intravenous dose of 4.2 (0.83) g infused over 1 h. The mean (+/‐ s.d.) volumes of distribution (VSS) of rac, (R)‐ and (S)‐ ifosfamide were 0.61 (0.17), 0.60 (0.16) and 0.61 (0.19) l kg‐1, respectively. The mean (+/‐ s.d.) half‐lives and clearances were 6.57 (1.69), 7.12 (1.92) and 5.98 (1.52) h and 0.065 (0.013), 0.060 (0.013) and 0.072 (0.014) l h‐1 kg‐1 for rac, (R)‐ and (S)‐ifosfamide, respectively. The half‐life of (S)‐ifosfamide was significantly (P < 0.001) shorter than that of (R)‐ifosfamide and it had a significantly higher clearance (P < 0.001). There was no significant difference in the volumes of distribution of the enantiomers. The clinical significance of the faster elimination of (S)‐ifosfamide is not known.
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