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Omentin: A Novel Link Between Inflammation, Diabesity, and Cardiovascular Disease

2010; Elsevier BV; Volume: 20; Issue: 5 Linguagem: Inglês

10.1016/j.tcm.2010.12.002

1873-2615

Bee K. Tan, Raghu Adya, Harpal S. Randeva,

Adipose Tissue and Metabolism

Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequelae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue-secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein-induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.