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Pulmonary Langerhans'-Cell Granulomatosis (Histiocytosis X)

2000; Massachusetts Medical Society; Volume: 342; Issue: 26 Linguagem: Inglês

10.1056/nejm200006293422605

1533-4406

Raanan Arens, Sandra S. Kramer,

Sarcoidosis and Beryllium Toxicity Research

Figure 1. A previously healthy 16-year-old girl presented with a three-day history of progressive pain on the left side of her chest. A chest x-ray film showed a large left-sided pneumothorax with bilateral cystic radiolucencies, and a chest tube was inserted. A high-resolution computed tomographic scan demonstrated the pneumothorax and multiple thin-walled cysts throughout the lungs, especially in the upper lobes (Panel A). Diagnostic thoracoscopy, with the endoscope inserted in the space around the chest tube, showed multiple subpleural cysts (Panel B). A thoracoscopic wedge-biopsy specimen was obtained. Histologic evaluation demonstrated nodular aggregates of Langerhans' cells (arrows in Panel C) . . .