The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration
2008; Lippincott Williams & Wilkins; Volume: 181; Issue: 2 Linguagem: Inglês
10.1016/j.juro.2008.10.030
ISSN1527-3792
AutoresIn Ho Chang, Seung Hyun Ahn, June Hyun Han, Tae‐Hyoung Kim, Young Sun Kim, Soon Chul Myung,
Tópico(s)Liver Disease Diagnosis and Treatment
ResumoNo AccessJournal of UrologyAdult Urology1 Feb 2009The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration In Ho Chang, Seung Hyun Ahn, June Hyun Han, Tae-Hyoung Kim, Young Sun Kim, and Soon Chul Myung In Ho ChangIn Ho Chang Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea , Seung Hyun AhnSeung Hyun Ahn KEPCO Medical Foundation, Hanil General Hospital, Seoul, Korea , June Hyun HanJune Hyun Han KEPCO Medical Foundation, Hanil General Hospital, Seoul, Korea , Tae-Hyoung KimTae-Hyoung Kim Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea , Young Sun KimYoung Sun Kim Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea , and Soon Chul MyungSoon Chul Myung Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea View All Author Informationhttps://doi.org/10.1016/j.juro.2008.10.030AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the association between body mass index and the concentration of tumor markers including carcinoembryonic antigen, α-fetoprotein, the carbohydrate antigen 19-9 and prostate specific antigen, as well as the association between body mass index changes and tumor marker concentration changes in a population of healthy men. Materials and Methods: We evaluated data on 8,776 men screened for tumor markers (carcinoembryonic antigen, α-fetoprotein, carbohydrate antigen 19-9 and prostate specific antigen) at least 3 times annually during an annual examination from 2001 to 2007. We assessed the tumor marker test findings for a trend in the age, alanine aminotransferase and creatinine adjusted tumor marker concentration by body mass index. We used multivariate regression analysis to determine whether a change in body mass index was associated with a tumor marker concentration change over time using calculated tumor markers, body mass index, creatinine and alanine aminotransferase concentration change per year. Results: After adjusting for age, creatinine and alanine aminotransferase a higher body mass index was associated with lower prostate specific antigen (p for trend <0.001), carcinoembryonic antigen (p for trend <0.001) and carbohydrate antigen 19-9 (p for trend <0.001). On multivariate regression analysis each 1 kg/m2 of body mass index gain per year was associated with a −0.011 ng/ml change in prostate specific antigen concentration, a –0.030 ng/ml change in carcinoembryonic antigen concentration and a −0.192 IU/ml change in carbohydrate antigen 19-9 concentration per year. Conclusions: In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual. References 1 : Changing trends of prostate cancer in Asia. Aging Male2004; 7: 120. Google Scholar 2 : Dietary fat, calories, and prostate cancer risk. J Natl Cancer Inst1999; 91: 489. Google Scholar 3 : Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst1997; 89: 385. 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Results from the REDUCE StudyJournal of Urology, VOL. 194, NO. 1, (52-57), Online publication date: 1-Jul-2015.Ohwaki K, Endo F, Muraishi O and Yano E (2018) Plasma Volume Changes Affect Prostate Specific Antigen in Healthy MenJournal of Urology, VOL. 183, NO. 4, (1349-1354), Online publication date: 1-Apr-2010.Steers W (2018) Food for Thought: Obesity as the Major Contributing Factor for Most Urological DisordersJournal of Urology, VOL. 181, NO. 5, (1983-1984), Online publication date: 1-May-2009. (2018) Reply by AuthorsJournal of Urology, VOL. 182, NO. 2, (497-498), Online publication date: 1-Aug-2009. Volume 181Issue 2February 2009Page: 567-573 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordshemodilutionobesitytumor markersbody mass indexbiologicalprostatic neoplasmsMetricsAuthor Information In Ho Chang Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea More articles by this author Seung Hyun Ahn KEPCO Medical Foundation, Hanil General Hospital, Seoul, Korea More articles by this author June Hyun Han KEPCO Medical Foundation, Hanil General Hospital, Seoul, Korea More articles by this author Tae-Hyoung Kim Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea More articles by this author Young Sun Kim Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea More articles by this author Soon Chul Myung Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea More articles by this author Expand All Advertisement PDF downloadLoading ...
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