Antichagasic Activity of Komaroviquinone Is Due to Generation of Reactive Oxygen Species Catalyzed by Trypanosoma cruzi Old Yellow Enzyme
2005; American Society for Microbiology; Volume: 49; Issue: 12 Linguagem: Inglês
10.1128/aac.49.12.5123-5126.2005
ISSN1098-6596
AutoresNahoko Uchiyama, Zakayi Kabututu, Bruno Kilunga Kubata, Fumiyuki Kiuchi, Michiho Ito, Junko Nakajima‐Shimada, Takashi Aoki, Kei Ohkubo, Shunichi Fukuzumi, Samuel K. Martin, Gisho Honda, Yoshihiro Urade,
Tópico(s)Biochemical and Molecular Research
ResumoABSTRACT A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.
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