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Blood Gas Changes in the Corpora Cavernosa: Metabolic and Histomorphometric Implications in the Patient with Erectile Dysfunction

2003; Lippincott Williams & Wilkins; Volume: 169; Issue: 6 Linguagem: Inglês

10.1097/01.ju.0000067910.36543.98

1527-3792

F. Sasso, Roberto Falabella, Giuseppe Gentile, C Servello, Gaetano Gulino,

Sexual Differentiation and Disorders

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2003Blood Gas Changes in the Corpora Cavernosa: Metabolic and Histomorphometric Implications in the Patient with Erectile Dysfunction F. SASSO, R. FALABELLA, G. GENTILE, C. SERVELLO, and G. GULINO F. SASSOF. SASSO , R. FALABELLAR. FALABELLA , G. GENTILEG. GENTILE , C. SERVELLOC. SERVELLO , and G. GULINOG. GULINO View All Author Informationhttps://doi.org/10.1097/01.ju.0000067910.36543.98AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated corpora cavernosa metabolism in flaccidity and in erection, analyzing some blood gas analytical parameters and comparing them by histomorphometric examination to find a direct relation between biochemical-metabolic parameters and histological data. Materials and Methods: We selected 33 patients with erectile dysfunction and divided them into 2 groups, including 1—those with congenital penile deviation who were responders to prostaglandin E1, and 2—those with severe organic erectile dysfunction who were not responders to prostaglandin E1. We evaluated O2 and CO2 pressure, pH and O2 saturation in blood samples. We then made a histomorphometric study of cavernous tissue. We obtained specimens by cavernous biopsies and calculated O2 and CO2 exchange, the Haldane effect and the respiratory quotient into the corpora cavernosa. All data were evaluated by statistical analysis. Results: Mean O2 arterial pressure and saturation ± SD were lower in group 2 than in group 1 (74.85 ± 8.78 versus 96.43 ± 14.87 and 94.98 ± 1.4 versus 97.35 ± 0.83, respectively). Mean CO2 arterial pressure was 35.59 ± 4.78 group 1 versus 38.8 ± 2.71 in group 2 with borderline statistical significance. The Haldane effect was superior in flaccidity than in erection because of the influence of arterial-venous O2 difference and the respiratory quotient, which was also an inverse ratio. Cavernous histomorphometry showed that in group 1 smooth muscle was a mean of 38.8 ± 8.94% of cavernous tissue versus 24.9% in group 2. Conclusions: Our study shows that starting with blood gas analytical data we can completely study the metabolism of the corpora cavernosa and its relationships to erectile dysfunction. Cavernous histomorphometry can suggest the presence of smooth muscle into cavernous tissue, whereas our mathematical elaboration allowed us to evaluate all data in a more complete manner. References 1 : Evaluation of vasculogenic impotence by monitoring of cavernous oxygen tension. J Urol1993; 149: 1276. Abstract, Google Scholar 2 Sasso F., Gulino G., Giovannini, Chiarla C., Matei D.V., Alcini E.: Evaluation of blood-gas changes in the corpora cavernosa after pharmacological stimulation. Presented at International Meeting on Corpus Cavernosum EMG and Standardization of Diagnostics in Erectile Dysfunction, Rome, Italy, March 29–30, 1996 Google Scholar 3 Sasso F., Matei D.V., Torricelli P., Fadda G., Balsamo G., Fiorino M.C., Gulino G.: Valutazione morfometrica del muscolo liscio nella struttura del corpo cavernosa-Rapporto preliminare. In: Andrologia 96, F. Menchini Fabris, P. Rossiand P. Turchi. X Congresso Nationale Societai Italiana Di Andrologia, Monduzzi, Editore, Pisa, Italy, October 16–19, 1996, 115–117, 1996 Google Scholar 4 : Calculation of venoarterial CO2 concentration difference. J Appl Physiol1993; 74: 959. Google Scholar 5 : The absorbition and dissociation of carbon dioxide by human blood. J Physiol1914; 48: 244. Google Scholar 6 : Hemoglobin and oxygen. In: Carbonic Acid and Acid-Base Balance. Baltimore: Williams & Wilkins Co.1931: 896. Google Scholar 7 : First Course in Numerical Analysis. New York: McGraw-Hill1978. sect. 8.4. Google Scholar 8 : Carbon dioxide transport. In: . Bethesda: American Physiological Society1987: 173. Google Scholar 9 : Distribution of electrolytes in human blood. J Biol Chem1961; 236: 1595. Google Scholar 10 : Mechanism and kinetics of the Haldane effect in human erythrocytes. J Appl Physiol1973; 35: 673. Google Scholar 11 : The respiratory quotient. Persp Crit Care1989; 2: 139. Google Scholar 12 : Anoxia and corporal smooth muscle dysfunction: a model for ischemic priapism. J Urol1994; 151: 259. Link, Google Scholar From the Department of Urology, Catholic University of the Sacred Heart, Rome, Italy© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 169Issue 6June 2003Page: 2270-2274 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsmuscle, smoothpenisblood gas analysisimpotenceMetricsAuthor Information F. SASSO More articles by this author R. FALABELLA More articles by this author G. GENTILE More articles by this author C. SERVELLO More articles by this author G. GULINO More articles by this author Expand All Advertisement PDF downloadLoading ...