Carta Acesso aberto Revisado por pares

Asthma 'Of Mice and Men'-How do animal models help us understand human asthma?

1994; Wiley; Volume: 24; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2222.1994.tb00909.x

ISSN

1365-2222

Autores

Ratko Djukanović,

Tópico(s)

Allergic Rhinitis and Sensitization

Resumo

Clinical & Experimental AllergyVolume 24, Issue 1 p. 6-9 Free Access Asthma ‘Of Mice and Men’–How do animal models help us understand human asthma? R. Djukanović, R. Djukanović Immunopharmacology Group, University Medicine, Centre Block, Level D. Southampton General Hospital, Southampton SO9 4XY, UK.Search for more papers by this author R. Djukanović, R. Djukanović Immunopharmacology Group, University Medicine, Centre Block, Level D. Southampton General Hospital, Southampton SO9 4XY, UK.Search for more papers by this author First published: January 1994 https://doi.org/10.1111/j.1365-2222.1994.tb00909.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Djukanović R, Roche WR. Wilson JW et al. Mucosal inflammation in asthma. State of the art. Am Rev Respir Dis 1990; 142: 434– 57. 2 Kirby JG, Hargreave FE, Gliech GJ, O'Byrne PM. Bron-choalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 1987; 136: 379– 83. 3 Beasley R, Roche WR, Roberts JA, Holgate ST. 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Increases in activated T lymphocytes, eosinophils and cytokine messenger RNA for IL-5 and GM-CSF in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am J Resp Cell Mol Biol 1993; 8: 35– 42. 39 Tsuji K, Nakahata T, Takagi M et al. Effects of interleukin 3 and interleukin 4 on the development of ‘connective tissue type’ mast cells: Interleukin 3 supports their survival and interleukin 4 triggers and supports their proliferation syner-gistically with interleukin 3. Blood 1990; 75: 421– 27. 40 Favre C, Sealand S, Caux C, Duvert V, De Vries JE. Interleukin 4 has basophilic and eosinophilic growth-promoting activity on cord blood cells. Blood 1990; 75: 67– 73. 41 Irani A-M A, Craig SS, De Blois G et al. Deficiency of the tryptase positive, chymasc negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function. J Immunol 1987; 138: 4381– 6. 42 Hamaguchi Y, Kanakura Y, Fujita J, Takeda SI. 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Intcrlcukins (IL)-4, -5, -6, and TNFα in normal and asthmatic airways: evidence for the human mast cell as an important source of these cytokines. Am J Respir Cell Mol Biol (in press). 47 Djukanovic R, Wilson JW, Britten KM et al. The effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992; 145: 669– 74. 48 Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Inhaled beclomethasone dipropionate down-regulates airway lymphocyte activation in atopic asthma. Am Rev Respir Dis 1993; (in press). 49 Robinson DS, Hamid Q, Ying S et al. Prednisolonc treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5 and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993; 148: 401– 6. Citing Literature Volume24, Issue1January 1994Pages 6-9 ReferencesRelatedInformation

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