Determination of Lovastatin (mevinolin) and mevinolinic acid in fermentation liquids
1993; Elsevier BV; Volume: 630; Issue: 1-2 Linguagem: Inglês
10.1016/0021-9673(93)80480-v
ISSN1873-3778
Autores Tópico(s)Microbial Natural Products and Biosynthesis
ResumoA rapid and simple HPLC method for the determination of Lovastatin (mevinolin) and mevinolinic acid in fermentation fluids of Aspergillus terreus using a Separon SGX C18 column and methanol-18 mM orthophosphoric acid (77.5:22.5, v/v) as mobile phase with detection at 238 nm is described. The detection limit of Lovastatin and mevinolinic acid was 20–30 ng/ml.
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