Interaction of carbamazepine and chlorpromazine in rabbits
1999; Wiley; Volume: 13; Issue: 7 Linguagem: Inglês
10.1002/(sici)1099-0801(199911)13
ISSN1099-0801
AutoresMarina D. Rukhadze, Maka M. Alexishvili, Vazha M. Okujava, T.G. Makharadze, Maya V. Sebiskveradze, Sonya K. Tsagareli,
Tópico(s)Plant-based Medicinal Research
ResumoBiomedical ChromatographyVolume 13, Issue 7 p. 445-449 Research Article Interaction of carbamazepine and chlorpromazine in rabbits Marina D. Rukhadze, Corresponding Author Marina D. Rukhadze Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaDepartment of Chemistry, Tbilisi State University, I. Chavchavadze ave 3, Tbilisi 380028, Republic of Georgia.Search for more papers by this authorMaka M. Alexishvili, Maka M. Alexishvili Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorVazha M. Okujava, Vazha M. Okujava Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorTeona G. Makharadze, Teona G. Makharadze Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorMaya V. Sebiskveradze, Maya V. Sebiskveradze Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorSonya K. Tsagareli, Sonya K. Tsagareli Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this author Marina D. Rukhadze, Corresponding Author Marina D. Rukhadze Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaDepartment of Chemistry, Tbilisi State University, I. Chavchavadze ave 3, Tbilisi 380028, Republic of Georgia.Search for more papers by this authorMaka M. Alexishvili, Maka M. Alexishvili Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorVazha M. Okujava, Vazha M. Okujava Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorTeona G. Makharadze, Teona G. Makharadze Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorMaya V. Sebiskveradze, Maya V. Sebiskveradze Laboratory of Neurobiology, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this authorSonya K. Tsagareli, Sonya K. Tsagareli Department of Chemistry, Tbilisi State University, I. Chavchavadze ave. 3, Tbilisi 380028, Republic of GeorgiaSearch for more papers by this author First published: 26 October 1999 https://doi.org/10.1002/(SICI)1099-0801(199911)13:7 3.0.CO;2-ZCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The interaction of carbamazepine and chlorpromazine in rabbits has been studied. The drugs were administrated as single oral doses (200 mg of each drug). The sequence of administration of the drugs was varied. It has been established that by simultaneous administration these drugs decrease absorption of each other in plasma. This may be explained by competition of the drugs to transfer from the gastrointestinal tract into plasma, as well as by the formation of complexes, more or less stable and more or less bound to gastrointestinal tissues. Carbamazepine intensifies the biotransformation of chlorpromazine, which may be caused by the ability of carbamazepine to induce microsomal liver enzymes. Chlorpromazine suppresses the biotransformation of carbamazepine, however. This may be caused by intensive capture of chlorpromazine by liver tissues and by its intensive biotransformation, which in turn is conditioned by its surface-active nature and by the increase of its metabolism with carbamazepine. Therefore the biotransformation of chlorpromazine is increased and metabolism of carbamazepine is reduced. The sequence of administration of the drugs affects their pharmacokinetics significantly. 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