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Skin repair and scar formation: the central role of TGF-β

2003; Cambridge University Press; Volume: 5; Issue: 8 Linguagem: Inglês

10.1017/s1462399403005817

1462-3994

Steven R. Beanes, Catherine Dang, Chia Soo, Kang Ting,

Periodontal Regeneration and Treatments

Wound healing is a complex process that we have only recently begun to understand. Central to wound repair is transforming growth factor β (TGF-β), a cytokine secreted by several different cell types involved in healing. TGF-β has diverse effects, depending upon the tissue studied. This review focuses on healing in skin, particularly the phases of cutaneous wound repair and the role of TGF-β in normal and impaired wound-healing models. It also explores TGF-β activity in scarless foetal wound healing. Knowledge of TGF-β function in scarless repair is critical to improving healing in clinical scenarios, such as diabetic wounds and hypertrophic scars.