Prostaglandin-oxytocin abortion: A clinical trial on intra-amniotic prostaglandin F2α in combination with intravenous oxytocin
1972; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês
10.1016/s0090-6980(72)80018-2
ISSN1878-416X
AutoresMarkku Seppälä, Pauli Kajanoja, O Wïdholm, Paavo Vara,
Tópico(s)Assisted Reproductive Technology and Twin Pregnancy
ResumoA clinical trial on the induction of midtrimester abortions was carried out on 57 women treated by intraamniotic administration of prostaglandin (PG) F2α, either alone or in combination with intravenous oxytocin. The mean induction-abortion interval was significantly shorter in the 36 women who received both PGF2α and oxytocin (17.3 hrs) than in the 21 women treated with PGF2α alone (26.6 hrs). Eighty-one per cent of the women in the PG-oxytocin group, and 43 % of the controls aborted within 24 hours, and abortion was achieved in 97 % and 86 % of the cases respectively, within 48 hours. Multigravid women aborted more quickly than primigravidae. The mean abortifacient dose of PGF2α was significantly reduced (from 36.6 to 26.4 mg, p < 0.001) by the simultaneous use of intravenous oxytocin. Our results suggest that oxytocin improves the clinical management of PGF2α-induced abortions.
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