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Finding a Cure for HIV: Much Work to Do

2014; American College of Physicians; Volume: 161; Issue: 5 Linguagem: Inglês

10.7326/m14-1573

1539-3704

Sharon R. Lewin,

HIV-related health complications and treatments

Editorials2 September 2014Finding a Cure for HIV: Much Work to DoSharon R. Lewin, FRACP, PhDSharon R. Lewin, FRACP, PhDFrom Alfred Health, Monash University, and Burnet Institute, Melbourne, Victoria, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-1573 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Antiretroviral therapy (ART) for HIV infection was one of the most spectacular scientific advances in recent decades. Patients who initiate ART at the right time can now have a normal life expectancy, and ART also dramatically reduces the risk for HIV transmission. However, treatment is not perfect. Lifelong ART is required, there are associated short- and long-term toxicities, and the drugs and health systems required to keep persons in long-term care come at a considerable cost (1). Therefore, there is a significantly renewed effort to find a cure for HIV (or a way to put HIV into remission) so patients ...References1. Maartens G, Celum C, Lewin SR. HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet. 2014. [PMID: 24907868] doi:10.1016/S0140-6736(14)60164-1 CrossrefMedlineGoogle Scholar2. Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, Taylor H, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387:183-8. [PMID: 9144289] CrossrefMedlineGoogle Scholar3. Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 2014. [PMID: 24968937] CrossrefMedlineGoogle Scholar4. Henrich TJ, Hanhauser E, Marty FM, Sirignano MN, Keating S, Lee TH, et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. 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N Engl J Med. 2014;370:901-10. [PMID: 24597865] doi:10.1056/NEJMoa1300662 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Alfred Health, Monash University, and Burnet Institute, Melbourne, Victoria, Australia.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-1573.Corresponding Author: Sharon R. Lewin, FRACP, PhD, Department of Infectious Diseases, Alfred Hospital, Level 2, Burnet Building, 85 Commercial Road, Melbourne, Victoria 3004, Australia; e-mail, s.[email protected]org.au.This article was published online first at www.annals.org on 22 July 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation Timothy J. Henrich , Emily Hanhauser , Francisco M. Marty , Michael N. Sirignano , Sheila Keating , Tzong-Hae Lee , Yvonne P. Robles , Benjamin T. Davis , Jonathan Z. Li , Andrea Heisey , Alison L. Hill , Michael P. Busch , Philippe Armand , Robert J. Soiffer , Marcus Altfeld , and Daniel R. Kuritzkes Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation Timothy J. Henrich , Emily Hanhauser , Francisco M. Marty , Michael N. Sirignano , Sheila Keating , Tzong-Hae Lee , Yvonne P. Robles , Benjamin T. Davis , Jonathan Z. Li , Andrea Heisey , Alison L. Hill , Michael P. Busch , Philippe Armand , Robert J. Soiffer , Marcus Altfeld , and Daniel R. Kuritzkes Metrics Cited ByEstablishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent ReservoirsTowards a scalable HIV cure research agenda: the role of co-infectionsExperiences and expectations of participants completing an HIV cure focused clinical trialHIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? 2 September 2014Volume 161, Issue 5Page: 368-369KeywordsAntiretroviral therapyCellsDNAHIVHIV infectionsImmune responseImmune systemT cellsToxicityTransplantation ePublished: 2 September 2014 Issue Published: 2 September 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...