Synthese d'aziridines secondaires substituees par un groupement trifluoromethyle
1989; Elsevier BV; Volume: 44; Issue: 2 Linguagem: Inglês
10.1016/s0022-1139(00)83941-x
ISSN1873-3328
AutoresK. Quinze, A. LAURENT, P. Mison, R. Faure,
Tópico(s)Chemical Synthesis and Analysis
ResumoSecondary aziridiness, substituted by a trifluoromethyl group were prepared by reacting Grignard reagents with oximes or a N,N,N-trimethylhydrazonium salt bearing a trifluoromethyl substituent. Contrary to the results obtained with hydrogenated substrates, ethyl magnesium bromide acted exclusively as a reducing agent. The structure of aziridine 5a was determined from X-ray crystallographic data. Secondary aziridiness, substituted by a trifluoromethyl group were prepared by reacting Grignard reagents with oximes or a N,N,N-trimethylhydrazonium salt bearing a trifluoromethyl substituent. Contrary to the results obtained with hydrogenated substrates, ethyl magnesium bromide acted exclusively as a reducing agent. The structure of aziridine 5a was determined from X-ray crystallographic data.
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