AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells
1995; Elsevier BV; Volume: 199; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(95)12029-4
ISSN1872-7972
AutoresPamela J. Middlemiss, Alvin J. Glasky, Michel P. Rathbone, Eva Werstuik, Shaun Hindley, John W. Gysbers,
Tópico(s)Neurogenesis and neuroplasticity mechanisms
ResumoAIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.
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