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The anabolic effects of parathyroid hormone therapy

2003; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês

10.1016/s0749-0690(02)00074-5

1879-8853

Mishaela R. Rubin, John P. Bilezikian,

Bone health and osteoporosis research

Until about 30 years ago, the predominant effects of parathyroid hormone (PTH) in the classic presentation of the disease primary hyperparathyroidism suggested that PTH was a catabolic hormone in the skeleton [ 1 Albright F. Aub J.C. Bauer W. Hyperparathyroidism: a common and polymorphic condition as illustrated by seventeen proven cases from one clinic. JAMA. 1934; 102: 1276-1287 Crossref Scopus (153) Google Scholar , 2 Albright F. Reifenstein E.C. The parathyroid glands and metabolic bone disease. Williams & Wilkins, Baltimore1948 Google Scholar ]. Although the skeleton can still be profoundly affected in severe primary hyperparathyroidism, classic radiographic features are rarely seen anymore. Rather than PTH being bad for bones, data have slowly accumulated over the years that provide another view of PTH—namely, that under certain circumstances, PTH is good for bones. This article summarizes this information with particular attention to the evidence that, in osteoporosis, PTH is an anabolic agent.