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Antimicrobial activity of naturally occurring and synthetic phloroglucinols against Staphylococcus aureus

1994; Wiley; Volume: 8; Issue: 2 Linguagem: Inglês

10.1002/ptr.2650080214

1099-1573

Masae Yamaki, Mikiko Miwa, Kyoko Ishiguro, Shuzo Takagi,

Carbohydrate Chemistry and Synthesis

Abstract Several phloroglucinols were isolated from Chinese drugs, Di er cao ( Hypericum japonicum Thunb.) and Xian he cao ( Agromonia pilosa Ledb.). These compounds showed potent activity against Staphylococcus aureus. Phloroglucinol derivatives were synthesized and their activities compared with naturally occurring and synthetic phloroglucinols against Staphylococcus aureus . The most active derivatives were methylene‐bis diacetyl‐phloroglucinol, n ‐butanoylphloroglucinol, sarothralin and uliginosin B.