How diverse should the immune system be?
1993; Royal Society; Volume: 252; Issue: 1335 Linguagem: Inglês
10.1098/rspb.1993.0062
ISSN1471-2954
AutoresRob J. de Boer, Alan S. Perelson,
Tópico(s)Blood groups and transfusion
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article De Boer Rob J and Perelson Alan. S. 1993How diverse should the immune system be?Proc. R. Soc. Lond. B.252171–175http://doi.org/10.1098/rspb.1993.0062SectionRestricted accessArticleHow diverse should the immune system be? Rob J De Boer Google Scholar Find this author on PubMed Search for more papers by this author and Alan. S. Perelson Google Scholar Find this author on PubMed Search for more papers by this author Rob J De Boer Google Scholar Find this author on PubMed and Alan. S. Perelson Google Scholar Find this author on PubMed Published:22 June 1993https://doi.org/10.1098/rspb.1993.0062AbstractWe develop a probability-based model that suggests a novel explanation for the enormous diversity of the lymphocyte repertoire in the immune system. Taking into account the fraction of the repertoire that is expected to be rendered tolerant because of potential self reactivity, we calculate PE, the probability that a pathogen escapes recognition by the immune system. Obviously, for PE to be low the diversity should be large. Our novel result is that the major factor in this relation between diversity and PE is formed by the number of self antigens. Thus our model suggests that, rather than the number of foreign antigens the system is protecting against, the diversity reflects the number of self antigens the immune system needs to avoid reactivity with.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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