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Cracking the carbohydrate code for selectin recognition

1995; Elsevier BV; Volume: 2; Issue: 11 Linguagem: Inglês

10.1016/1074-5521(95)90096-9

1879-1301

Carolyn R. Bertozzi,

Immune Response and Inflammation

Selectins are central in the inflammatory response; the discovery that they bind to carbohydrate ligands has galvanized carbohydrate chemists to search for inhibitors of the process. Recent progress in identifying and analyzing physiological selectin counter-receptors suggests new approaches to the design of ligands that bind to specific selectins.