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Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana

2008; American Chemical Society; Volume: 71; Issue: 8 Linguagem: Inglês

10.1021/np8001282

1520-6025

Pei-Hsuan Chuang, Pei‐Wen Hsieh, Yuliang Yang, Kuo-Feng Hua, Fang‐Rong Chang, Jentaie Shiea, Shih-Hsiung Wu, Yang‐Chang Wu,

Phytochemical compounds biological activities

Four new cyclopeptides, cyclomontanins A−D (1−4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.