Porokeratosis and Cutaneous Malignancy
1996; Lippincott Williams & Wilkins; Volume: 22; Issue: 4 Linguagem: Inglês
10.1111/j.1524-4725.1996.tb00327.x
ISSN1524-4725
AutoresMarvin Sasson, ABIGAIL D. KRAIN,
Tópico(s)Nonmelanoma Skin Cancer Studies
ResumoBACKGROUND Porokeratosis is a disorder of epidermal kerntinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy. OBJECTIVE The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk. METHODS All cases in the English language literature in the last 30 years were reviewed. RESULTS Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor. CONCLUSION Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.
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