Synthesis and anti-inflammatory activity of three nitro chalcones
2013; Elsevier BV; Volume: 23; Issue: 20 Linguagem: Inglês
10.1016/j.bmcl.2013.08.061
ISSN1464-3405
AutoresAbraham Gómez‐Rivera, Hidemí Aguilar-Mariscal, Nancy Romero‐Ceronio, Luis F. Roa, Carlos E. Lobato‐García,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoThe aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.
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