Monoclonal gammopathy with an insulin binding IgG(K) M‐component, associated with severe hypoglycaemia
1986; Wiley; Volume: 62; Issue: 4 Linguagem: Inglês
10.1111/j.1365-2141.1986.tb04091.x
ISSN1365-2141
AutoresWim J. Sluiter, J. Marrink, B Houwen,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoSummary A case is described in which a monoclonal gammopathy was associated with postprandial hypoglycaemia, resulting from insulin binding by the M‐component. The monoclonal immunoglobulin possessed a low affinity for insulin, but its binding capacity was very high. Cytotoxic chemotherapy and diazoxide treatment failed to prevent severe hypoglycaemic attacks.
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