Measurement and Prediction of Thermal Behavior and Acute Assessment of Injury in a Pig Model of Renal Cryosurgery
2001; Mary Ann Liebert, Inc.; Volume: 15; Issue: 2 Linguagem: Inglês
10.1089/089277901750134584
ISSN1557-900X
AutoresF. Schmidlin, Christopher C. Rupp, Nathan E. Hoffmann, James E. Coad, David J. Swanlund, John C. Hulbert, John C. Bischof,
Tópico(s)Renal and related cancers
ResumoTo analyze in vivo end temperatures and histologic injury in a standardized cryo-iceball using a porcine kidney model in order to establish the threshold temperature for tissue ablation. To evaluate the ability to predict end temperatures using a thermal finite element model.A single freeze/thaw cryolesion was created in five pig kidneys and the temperature history recorded. End temperature was calculated using a thermal finite element model. The threshold temperature for tissue injury was established by directly correlating end temperature and histologic injury.Reproducible geometry and temperature profiles of the cryo-iceball were found. End temperature could be accurately predicted through thermal modeling, and correlation with histologic injury revealed a threshold temperature of -16.1 degrees C for complete tissue ablation.Thermal modeling may accurately predict end temperature within a cryo-iceball. Provided threshold temperatures for tissue destruction are known, modeling may become a powerful tool in cryosurgery, improving the assessment of damage in normal and malignant tissue.
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