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Deficiency in monocyte chemoattractant protein-1 modifies lipid and glucose metabolism

2007; Elsevier BV; Volume: 83; Issue: 3 Linguagem: Inglês

10.1016/j.yexmp.2007.08.003

1096-0945

Anna Rull, Joan Carles Escolà‐Gil, Josep Julve, Noemí Rotllán, Laura Calpe‐Berdiel, Blai Coll, Gerard Aragonès, Judit Marsillach, Carlos Alonso‐Villaverde, Jordi Camps, Francisco Blanco‐Vaca, Jorge Joven,

Immune Cell Function and Interaction

We describe the effect of MCP-1 deficiency in mice rendered hyperlipemic by the concomitant ablation of the LDL receptor. The MCP-1(-/-)LDLr(-/-) mice in comparison with LDLr(-/-) mice showed a decreased lipoprotein clearance, derangements in free fatty acids delivery and less glucose tolerance when fed a regular chow, and they showed a partial resistance to alterations in glucose and lipid metabolism induced by dietary fat and cholesterol. They also were less prone to the development of diet-induced obesity. Our results suggest that the role of MCP-1 in metabolism is relevant and that, although new hidden complexities are evident, the function of MCP-1/CCL2 extends far beyond the monocyte chemoattractant effect. Therefore, the regulatory mechanisms influenced by MCP-1 should be fully ascertained to understand the metabolic consequences of inflammation and before considering MCP-1 as a therapeutic target.