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Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.

1990; Japan Society of Cell Biology; Volume: 15; Issue: 5 Linguagem: Inglês

10.1247/csf.15.295

1347-3700

J Nozaki-Renard, Takashi Iino, Yoshinari Sato, Yasumasa Marumoto, Genkichi Ohta, Mitsuru Furusawa,

Immune Cell Function and Interaction

Infection of the human lymphocyte CEM cell line with the HIV-1 (human immunodeficiency virus-1, LAV-1 strain) results in cell death. A fluoroquinolone antibiotic, ofloxacin, protected the infected cells from HIV-1-mediated cytolysis. Other fluoroquinolones, e.g. ciprofloxacin, norfloxacin, and enoxacin, also protected the infected cells from HIV-1-mediated cytolysis. The d-isomer of ofloxacin (DR-3354) was about 50-fold less effective than the l-isomer (DR-3355). Almost none of the rescued cells had detectable HIV-antigens and they could be maintained for long periods in vitro without drugs.