Portal de Periódicos da CAPES

The use of chlorpromazine for symptom control in dying cancer patients

1994; Elsevier BV; Volume: 9; Issue: 5 Linguagem: Inglês

10.1016/0885-3924(94)90193-7

1873-6513

Beth McIver, Declan Walsh, Kristine A. Nelson,

Pain Management and Opioid Use

Tenninal restlessness is a signijicant problem in deaths from advanced cancm; it is dij$cult not only for patients, but for family and ha&h-care providers &o. Chknpomazine is an antipsychotic phenothiarine, safe at high doses and by many roukx It has also been Itied cw an adjunct to mo$hine in advanced cancer. We have conducted a study using chlorp-omarine in 20 patients, in which the drug was administered intravenously (IV) or rectally (PR) in inpatients and outpatients for terminal restlessness and dyspnea. The median PR ok was 25mg every 612 hr.The median IV dose was 12.5 mg every 4-12 hr.Eighteen patients had complete relief and two had partial relief before death.We find ch@fmnnazine safe a-ad effective fm the relief of terminal restlessness and dyspnea in advanced cancer.