e nt -Rosane and Labdane Diterpenoids from Sagittaria s agittifolia and Their Antibacterial Activity against Three Oral Pathogens
2006; American Chemical Society; Volume: 69; Issue: 2 Linguagem: Inglês
10.1021/np050479e
ISSN1520-6025
AutoresXueting Liu, Qin Pan, Yao Shi, Ian D. Williams, Herman H. Y. Sung, Qiong Zhang, Jingyu Liang, Nancy Y. Ip, Zhi‐Da Min,
Tópico(s)Phytochemical Studies and Bioactivities
ResumoSeven new ent-rosane diterpenoids, sagittines A−G (1−7), together with one new labdane diterpene, 13-epi-manoyl oxide-19-O-α-l-2',5'-diacetoxyarabinofuranoside (8), were isolated from the whole plant of Sagittaria sagittifolia. The structures and relative configurations of 1−8 were characterized using spectroscopic means, chemical methods, and X-ray crystallography. Compounds 1−4 exhibited antibacterial activity against the oral pathogens Streptococcus mutans ATCC 25175 and Actinomyces naeslundiis ATCC 12104, with MIC values between 62.5 and 125 μg/mL. Compound 5 was active against only A. naeslundiis ATCC 12104, with an MIC value of 62.5 μg/mL.
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