Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
2002; American Association for the Advancement of Science; Volume: 295; Issue: 5556 Linguagem: Inglês
10.1126/science.1067389
ISSN1095-9203
AutoresPavan K. Auluck, Ho Yin Edwin Chan, John Q. Trojanowski, Virginia M.‐Y. Lee, Nancy M. Bonini,
Tópico(s)Calpain Protease Function and Regulation
ResumoParkinson's disease is a movement disorder characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in Drosophila melanogaster upon directed expression of alpha-synuclein, a protein implicated in the pathogenesis of Parkinson's disease and a major component of proteinaceous Lewy bodies. We report that directed expression of the molecular chaperone Hsp70 prevented dopaminergic neuronal loss associated with alpha-synuclein in Drosophila and that interference with endogenous chaperone activity accelerated alpha-synuclein toxicity. Furthermore, Lewy bodies in human postmortem tissue immunostained for molecular chaperones, also suggesting that chaperones may play a role in Parkinson's disease progression.
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