Highly Stereoselective Synthesis of β -Amino Ketones via a Mannich Reaction Catalyzed by Cellulose Sulfuric Acid as a Biodegradable, Efficient, and Recyclable Heterogeneous Catalyst
2011; Taylor & Francis; Volume: 41; Issue: 24 Linguagem: Inglês
10.1080/00397911.2010.520101
ISSN1532-2432
AutoresFirouzeh Nemati, Amir Soheyl Fakhaei, Ali Amoozadeh, Yaser Saeidi Hayeniaz,
Tópico(s)Chemical Synthesis and Reactions
ResumoAbstract The efficient use of cellulose sulfuric acid as a heterogeneous catalyst promotes three-component, one-pot Mannich reaction of various ketones, aromatic aldehydes, and aromatic amines in ethanol to make the corresponding β-amino ketones with high stereoselectivity in favor of the anti-isomer. This protocol has several advantages such as good yield, mild reaction conditions, no environmental hazards, and simple workup procedure.
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