Induction of Ca 2+ /calmodulin‐dependent NO synthase in various organs of rats by Propionibacterium acnes and lipopolysaccharide treatment
1992; Wiley; Volume: 308; Issue: 1 Linguagem: Inglês
10.1016/0014-5793(92)81041-j
ISSN1873-3468
AutoresShinobu Oguchi, Sachio Iida, Hiroko Adachi, Hiroshi Ohshima, Hiroyasu Esumi,
Tópico(s)Renin-Angiotensin System Studies
ResumoCa 2+ /calmodulin‐dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats. Examination of the specific induction of C a2+ /calmodulin‐dependent NO synthase showed that the enzyme was induced in the lung, spleen and colon as well as the liver. Northern blot analysis revealed that the induction occurred at the transcriptional level.
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