Portal de Periódicos da CAPES

Localized scleroderma associated with progressing ischemic stroke

1999; Elsevier BV; Volume: 163; Issue: 1 Linguagem: Inglês

10.1016/s0022-510x(98)00267-6

1878-5883

Naomi Kanzato, Toshio Matsuzaki, Yukihiro Komine, Mineki Saito, Akiko Saito, Taku Yoshio, Masahito Suehara,

Sarcoidosis and Beryllium Toxicity Research

Abstract We present a 73 year-old Japanese woman with localized scleroderma involving the right side of the scalp accompanied by continuous tingling pain, who developed insidiously progressive left hemiparesis. In magnetic resonance imaging of the brain, an infarct first appeared in the watershed region of the right middle cerebral artery territory and subsequently extended to deep white matter accompanied by scattered hemorrhages. Focal stenosis in the M2 portion of the right middle cerebral artery was revealed on magnetic resonance angiography, and the distal vessels were only shown faintly. A biopsy specimen from the sclerotic scalp lesion showed obvious thickening of vessel walls and mild mononuclear cell infiltration. We believe that the progressing ischemic stroke was caused by hemodynamic disturbances from localized sclerotic obstruction of the middle cerebral artery, with an autoimmune pathogenesis.