Onychomycosis due to <i>Exophiala jeanselmei</i>
2002; Karger Publishers; Volume: 204; Issue: 2 Linguagem: Inglês
10.1159/000051836
ISSN1421-9832
AutoresAnne‐Marie Boisseau‐Garsaud, N. Desbois, Marie-Laurence Guillermin, Marlène Ossondo, Evelyne Gueho, D Calès-Quist,
Tópico(s)Antifungal resistance and susceptibility
Resumo<i>Background:</i><i>Exophiala jeanselmei</i> is a dematiaceous fungus that may cause invasive diseases, particularly among immunocompromised hosts. Most reports mention cutaneous or subcutaneous lesions, but no case of nail involvement due to this fungus has been reported until now. <i>Case Report:</i> A 60-year-old man presented with hyperkeratosis and black coloration of the nails of the two thumbs and the two big toes of 4 years’ duration. He was a renal transplant recipient and had been treated with prednisone and azathioprine. <i>E. jeanselmei</i> was present on direct examination, then isolated in cultures on repeated samplings from all pathologic nails. He was cured after 6 months of treatment with itraconazole. <i>Commentary:</i> We describe the first case of nail infection due to <i>E. jeanselmei.</i> Itraconazole, which provides a broad spectrum of action on fungal species and achieves high levels of active substance in many tissues, including the nails, appeared to be efficient upon such a nail localization of <i>E. jeanselmei.</i>
Referência(s)