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Cardiovascular adverse effects of injected nanocarriers: Autonomic dysregulation

2013; Elsevier BV; Volume: 177; Issue: 1 Linguagem: Inglês

10.1016/j.autneu.2013.05.089

1872-7484

M. A. Vlasova, О. С. Тарасова, Joakim Riikonen, Janne Raula, A. S. Lobach, Anna A. Borzykh, Boris V. Smirin, Esko I. Kauppinen, Alexander V. Eletskii, Karl‐Heinz Herzig, Jarno Salonen, Pasi Tavi, Vesa‐Pekka Lehto, Kristiina Järvinen,

Heart rate and cardiovascular health

Nanocarriers can often achieve superior therapeutic outcomes for drug delivery when compared with standard drug formulations. However, concerns over their adverse effects are growing due to the correlation between exposure to nanosized particles and cardiovascular diseases. Here we examine the impact of intravenously injected drug-free nanocarriers on the cardiovasculature at both systemic and organ levels. We combine in vivo and in vitro methods to enable monitoring of hemodynamic parameters in conscious rats, assessments of the function of the vessels after sub-chronic systemic exposure to nanocarriers and evaluation of the direct effect of nanocarriers on vascular tone.