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Comparative Pharmacological and Toxicological Evaluation of N-Acetyl-p-Aminophenol, Salicylamide, and Acetylsalicylic Acid**Department of Pharmacology, Research Division, Mead Johnson and Co., Evansville, Ind.

1958; Elsevier BV; Volume: 47; Issue: 7 Linguagem: Inglês

10.1002/jps.3030470706

1930-2304

Gale C. Boxill, Clinton B. Nash, Allan G. Wheeler,

Biochemical Acid Research Studies

Acute toxicity studies on N-acetyl-p-aminophenol (NAPAP), salicylamide (SAM), and acetylsalicylic acid (ASA) revealed that NAPAP was least toxic (LDSo) in rats and guinea pigs while SAM was least toxic in mice. As antipyretic agents NAPAP and ASA were approximately equivalent in potency and both were more effective than SAM. A consideration of the ratio of the minimum neurological deficit doseio (TDso) and the minimum effective antipyretic dose indicated that NAPAP and ASA had a wider safety margin than SAM. ASA produced tachycardia, pyrexia, polypnea, and an increase in tidal volume. NAPAP and SAM produced little change in blood pH, tidal volume, respiratory rate, and heart rate. Myocardial depression was seen with ASA and SAM but not with NAPAP.