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Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi

2009; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1016/j.mib.2009.09.015

1879-0364

Hugo Lavoie, Hervé Hogues, Malcolm Whiteway,

Fungal Biology and Applications

Growing evidence suggests that transcriptional regulatory networks in many organisms are highly flexible. Here, we discuss the evolution of transcriptional regulatory networks governing the metabolic machinery of sequenced ascomycetes. In particular, recent work has shown that transcriptional rewiring is common in regulons controlling processes such as production of ribosome components and metabolism of carbohydrates and lipids. We note that dramatic rearrangements of the transcriptional regulatory components of metabolic functions have occurred among ascomycetes species.